Development of a gel-in-oil emulsion as a transdermal drug delivery system for successful delivery of growth factors

Growth factors (GFs) are indispensable in regenerative medicine because of their high effectiveness. However, as GFs degenerate easily, the development a suitable carrier with improved stability for is necessary. In this study, we developed gel-in-oil (G/O) emulsion technology transdermal delivery growth factors. Nanogel particles prepared heparin-immobilized gelatin that can bind were dispersed isopropyl myristate. The particle size G/O could be controlled by changing surfactant concentration, volume ratio water phase to oil phase, and concentration. vitro skin penetration studies showed better through stratum corneum fluorescent proteins containing emulsions than aqueous solution GF. Similarly, an vivo study angiogenesis-inducing effect after application GF-immobilized emulsion. Angiogenesis mice was confirmed owing both increased blood vessel network higher hemoglobin content blood. Therefore, promising effectively deliver at target site.